PAPER: Nicotine in cigarettes linked to breast cancer..

August 24, 2010 - Normal cigarettes are known to contain at least 60 cancer-causing substances including carbon monoxide, tar and arsenic, but until now nicotine had not been on the list. Researchers from Taipei Medical University looked looked at both breast cancer cells and normal cells to see if nicotine promoted tumour growth at a cellular level. It is the first time nicotine has been implicated as one of the chemicals in cigarettes that can trigger the development of breast cancer.

Dr Yuan-Soon Ho and his team found that when normal cells were treated with nicotine in the laboratory it promoted the development of cancer characteristics. Likewise reducing the level of nicotine inhibited tumour growth.

The findings, published in The Journal of the National Cancer Institute, could be a major blow to makers of nicotine-based products that help smokers to quit. The research could have a negative impact on companies that make nicotine gum, patches and electronic cigarettes that are promoted as a 'healthy alternative' for smokers.

MEMO TO THE MEDIA: Nicotine binding to receptor linked to breast cancer cell growth, Journal of the National Cancer Institute Advance Access published online on August 23, 2010, FULL TEXT

PAPER: Overexpression and Activation of the {alpha}9-Nicotinic Receptor During Tumorigenesis in Human Breast Epithelial Cells, Chia-Hwa Lee, Ching-Shui Huang, Ching-Shyang Chen, Shih-Hsin Tu, Ying-Jan Wang, Yu-Jia Chang, Ka-Wai Tam, Po-Li Wei, Tzu-Chun Cheng, Jan-Show Chu, Li-Ching Chen, Chih-Hsiung Wu, Yuan-Soon Ho, Journal of the National Cancer Institute Advance Access published online on August 23, 2010, ABSTRACT..

In an accompanying editorial, Ilona Linnoila, M.D., of the Center for Cancer Research at the National Cancer Institute, writes that the study "suggests not only that smoking could be causally related to breast carcinogenesis but also that nicotine could directly contribute to the molecular mechanism of carcinogenesis in addition to indirectly contributing by promoting addiction to smoking."

EDITORIAL: From Nicotine to Breast Cancer, Implications of Cholinergic Receptor Pathway, R. Ilona Linnoila Experimental Pathology Section, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, Journal of the National Cancer Institute Advance Access published online on August 23, 2010,
FULL TEXT..

Reference: Nicotine in cigarettes linked to breast cancer for the first time by Claire Bates, DailyMail.co.uk, 8/24/2010.

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